Version 5.4
Homo sapiens Gene: HSPA14
Summary
InnateDB Gene IDBG-55933.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPA14
Gene Name heat shock 70kDa protein 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187522
Encoded Proteins
IDBP-55935
heat shock 70kDa protein 14
IDBP-366741
heat shock 70kDa protein 14
IDBP-366745
heat shock 70kDa protein 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21730052
HSPA14 binds directly to TLR4 on dendritic cell surfaces and induces a robust Th1 response via the MAPK and NFkB signalling pathways.
InnateDB Annotation from Orthologs
Summary
PMID 21730052
[Mus musculus] Hspa14 binds directly to Tlr4 on dendritic cell surfaces and induces a robust Th1 response via the MAPK and NFkB signalling pathways.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:14838164-14871741
Strand Forward strand
Band p13
Transcripts
ENST00000378372 ENSP00000367623
ENST00000437161 ENSP00000390513
ENST00000441647 ENSP00000404691
ENST00000493863
ENST00000493178
ENST00000470430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006950 response to stress
GO:0045087 innate immune response (InnateDB)
GO:0051083 'de novo' cotranslational protein folding
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051396
View Gene Order
ENSBTAG00000016451
Not yet available
Cross-References
SwissProt
TrEMBL B0YIZ1
UniProt Splice Variant
Entrez Gene 51182
UniGene Hs.604792 Hs.731745 Hs.736996
RefSeq NM_001278205 NM_016299
HUGO HGNC:29526
OMIM 610369
CCDS CCDS60487 CCDS7103
HPRD 07021
IMGT
EMBL AC069544 CH471072 EF444968
GenPept ACA05967 EAW86259
RNA Seq Atlas 51182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca