Version 5.4
Homo sapiens Gene: HUS1B
Summary
InnateDB Gene IDBG-55943.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HUS1B
Gene Name HUS1 checkpoint homolog b (S. pombe)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188996
Encoded Proteins
IDBP-55945
HUS1 checkpoint homolog b (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:655939-656963
Strand Reverse strand
Band p25.3
Transcripts
ENST00000380907 ENSP00000370293
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006281 DNA repair
Cellular Component
GO:0005730 nucleolus
GO:0030896 checkpoint clamp complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000076430
View Gene Order
Cross-References
SwissProt Q8NHY5
TrEMBL
UniProt Splice Variant
Entrez Gene 135458
UniGene Hs.669039
RefSeq NM_148959
HUGO HGNC:16485
OMIM 609713
CCDS CCDS4470
HPRD
IMGT
EMBL AF508547 AL357054 BC101697 BC101699
GenPept AAI01698 AAI01700 AAM28904 CAI15190
RNA Seq Atlas 135458

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca