InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP26B1

Summary

InnateDB Gene

IDBG-56115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP26B1

Gene Name

cytochrome P450, family 26, subfamily B, polypeptide 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000003137

Encoded Proteins

IDBP-56117

cytochrome P450, family 26, subfamily B, polypeptide 1

IDBP-379831

cytochrome P450, family 26, subfamily B, polypeptide 1

IDBP-475412

cytochrome P450, family 26, subfamily B, polypeptide 1

IDBP-484575

cytochrome P450, family 26, subfamily B, polypeptide 1

IDBP-594577

cytochrome P450, family 26, subfamily B, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:72129238-72148038

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000001146	ENSP00000001146
ENST00000412253	ENSP00000401465
ENST00000474509	ENSP00000430888
ENST00000461519	ENSP00000430871
ENST00000546307	ENSP00000443304

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0005506	iron ion binding
GO:0008401	retinoic acid 4-hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0001709	cell fate determination
GO:0006766	vitamin metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007140	male meiosis
GO:0007283	spermatogenesis
GO:0009954	proximal/distal pattern formation
GO:0010628	positive regulation of gene expression
GO:0030326	embryonic limb morphogenesis
GO:0034653	retinoic acid catabolic process
GO:0042573	retinoic acid metabolic process
GO:0043587	tongue morphogenesis
GO:0044281	small molecule metabolic process
GO:0048384	retinoic acid receptor signaling pathway
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0055114	oxidation-reduction process
GO:0060349	bone morphogenesis
GO:0061436	establishment of skin barrier
GO:0070268	cornification
GO:0071300	cellular response to retinoic acid
GO:2001037	positive regulation of tongue muscle cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000063415

View Gene Order

ENSBTAG00000012212

Not yet available

Pathways

NETPATH

REACTOME

REACT_13450

Vitamins pathway

REACT_13567

Cytochrome P450 - arranged by substrate type pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

REACT_13705

Phase 1 - Functionalization of compounds pathway

KEGG

hsa00830

Retinol metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.91546

RefSeq

NM_001277742 NM_019885 XM_005264433

HUGO

OMIM

CCDS

CCDS1919 CCDS62934

HPRD

05550

IMGT

EMBL

GenPept

RNA Seq Atlas