Version 5.4
Homo sapiens Gene: GABRA6
Summary
InnateDB Gene IDBG-56309.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRA6
Gene Name gamma-aminobutyric acid (GABA) A receptor, alpha 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145863
Encoded Proteins
IDBP-56311
gamma-aminobutyric acid (GABA) A receptor, alpha 6
IDBP-479318
gamma-aminobutyric acid (GABA) A receptor, alpha 6
IDBP-477495
gamma-aminobutyric acid (GABA) A receptor, alpha 6
IDBP-480453
gamma-aminobutyric acid (GABA) A receptor, alpha 6
IDBP-482956
gamma-aminobutyric acid (GABA) A receptor, alpha 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:161547063-161702593
Strand Forward strand
Band q34
Transcripts
ENST00000274545 ENSP00000274545
ENST00000522269
ENST00000518888
ENST00000523217 ENSP00000430527
ENST00000524220
ENST00000520000 ENSP00000429943
ENST00000517823 ENSP00000430212
ENST00000523691 ENSP00000427989
ENST00000521520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
GO:0008503 benzodiazepine receptor activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007165 signal transduction
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020428
View Gene Order
ENSBTAG00000013262
Not yet available
Pathways
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_24987
GABA A receptor activation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YBS7
UniProt Splice Variant
Entrez Gene 2559
UniGene Hs.739529 Hs.90791
RefSeq NM_000811
HUGO HGNC:4080
OMIM 137143
CCDS CCDS4356
HPRD 08841
IMGT
EMBL AC091944 AC091989
GenPept
RNA Seq Atlas 2559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca