Version 5.4
Mus musculus Gene: Gabra6
Summary
InnateDB Gene IDBG-163638.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gabra6
Gene Name gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
Synonyms alpha6; GABA-ARalpha6; Gabra-6
Species Mus musculus
Ensembl Gene ENSMUSG00000020428
Encoded Proteins
IDBP-163640
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
IDBP-262714
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
IDBP-628204
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145863:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:42306437-42321072
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000020703 ENSMUSP00000020703
ENSMUST00000109286 ENSMUSP00000104909
ENSMUST00000155218 ENSMUSP00000126114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145863
View Gene Order
ENSBTAG00000013262
Not yet available
Pathways
NETPATH
REACTOME
REACT_198560
GABA A receptor activation pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_268398
Orphan transporters pathway
REACT_198558
Ligand-gated ion channel transport pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_224131
GABA receptor activation pathway
REACT_259290
Neuronal System pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_24987
GABA A receptor activation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P16305
TrEMBL
UniProt Splice Variant
Entrez Gene 14399
UniGene Mm.4915
RefSeq NM_001099641 NM_008068 XM_006532198
OMIM
CCDS CCDS24554 CCDS48769
HPRD
IMGT
MGI ID MGI:95618
MGI Symbol Gabra6
EMBL AF256197 AF256198 AK135145 AL645823 BC145158 BC145702 U77409 U77410 U77411 X51986
GenPept AAD52001 AAD52002 AAD52003 AAD52004 AAG28024 AAG28025 AAI45159 AAI45703 BAE22438 CAA36244 CAI24931
RNA Seq Atlas 14399

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca