Version 5.4
Homo sapiens Gene: NAT8
Summary
InnateDB Gene IDBG-56565.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAT8
Gene Name N-acetyltransferase 8 (GCN5-related, putative)
Synonyms ATase2; CML1; GLA; Hcml1; TSC501; TSC510
Species Homo sapiens
Ensembl Gene ENSG00000144035
Encoded Proteins
IDBP-56567
N-acetyltransferase 8 (GCN5-related, putative)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008] This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008]
This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:73640832-73642393
Strand Reverse strand
Band p13.1
Transcripts
ENST00000272425 ENSP00000272425
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008080 N-acetyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0008152 metabolic process
GO:0042493 response to drug
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9UHE5
TrEMBL
UniProt Splice Variant
Entrez Gene 9027
UniGene Hs.728429
RefSeq NM_003960 NM_016347
HUGO HGNC:18069
OMIM 606716 608190
CCDS CCDS1926
HPRD
IMGT
EMBL AB013094 AB019551 AF187813 BC012626 CR407610
GenPept AAF22303 AAH12626 BAA33679 BAA34386 CAG28538
RNA Seq Atlas 51471 9027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca