Version 5.4
| Homo sapiens Protein: NAT8 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-56567.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | NAT8 | ||||||||||||||||||
| Protein Name | N-acetyltransferase 8 (GCN5-related, putative) | ||||||||||||||||||
| Synonyms | ATase2; CML1; GLA; Hcml1; TSC501; TSC510; | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000272425 | ||||||||||||||||||
| InnateDB Gene | IDBG-56565 (NAT8) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). {ECO:0000269PubMed:19011241, ECO:0000269PubMed:20392701, ECO:0000269PubMed:24556617}. | ||||||||||||||||||
| Subcellular Localization | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | Preferentially expressed in liver and kidney. Also detected in brain (at protein level). {ECO:0000269PubMed:22267734, ECO:0000269PubMed:9852678}. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR000182
GNAT domain IPR013653 FR47-like IPR016181 Acyl-CoA N-acyltransferase |
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| PFAM |
PF00583
PF13302 PF13508 PF13673 PF13718 PF08445 |
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| PRINTS | |||||||||||||||||||
| PIRSF | |||||||||||||||||||
| SMART | |||||||||||||||||||
| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9UHE5 | ||||||||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 9027 | ||||||||||||||||||
| UniGene | Hs.728429 | ||||||||||||||||||
| RefSeq | NP_057431 | ||||||||||||||||||
| HUGO | HGNC:18069 | ||||||||||||||||||
| OMIM | 608190 | ||||||||||||||||||
| CCDS | CCDS1926 | ||||||||||||||||||
| HPRD | 08413 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB013094 AB019551 AF187813 BC012626 CR407610 | ||||||||||||||||||
| GenPept | AAF22303 AAH12626 BAA33679 BAA34386 CAG28538 | ||||||||||||||||||