Homo sapiens Gene: TOMM40
Summary
InnateDB Gene IDBG-56765.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol TOMM40
Gene Name translocase of outer mitochondrial membrane 40 homolog (yeast)
Synonyms C19orf1; D19S1177E; PER-EC1; PEREC1; TOM40;
Species Homo sapiens
Ensembl Gene ENSG00000130204
Encoded Proteins
translocase of outer mitochondrial membrane 40 homolog (yeast)
translocase of outer mitochondrial membrane 40 homolog (yeast)
translocase of outer mitochondrial membrane 40 homolog (yeast)
Protein Structure
Entrez Gene
Summary TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45393826-45406946
Strand Forward strand
Band q13.32
Transcripts
ENST00000252487 ENSP00000252487
ENST00000405636 ENSP00000385184
ENST00000426677 ENSP00000410339
ENST00000592041 ENSP00000465608
ENST00000592434 ENSP00000466084
ENST00000589649 ENSP00000465032
ENST00000589253 ENSP00000465611
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008308 voltage-gated anion channel activity
GO:0008320 protein transmembrane transporter activity
GO:0015288 porin activity
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0006820 anion transport
GO:0044070 regulation of anion transport
GO:0044267 cellular protein metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005742 mitochondrial outer membrane translocase complex
GO:0016021 integral to membrane
GO:0031307 integral to mitochondrial outer membrane
GO:0032592 integral to mitochondrial membrane
GO:0046930 pore complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mitochondrial Protein Import pathway
KEGG
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O96008
TrEMBL
UniProt Splice Variant
Entrez Gene 10452
UniGene Hs.655909
RefSeq NM_001128916 NM_001128917 NM_006114
HUGO 18001
OMIM 608061
CCDS CCDS12646
HPRD 16274
IMGT
EMBL AF043250 AF043251 AF043252 AF043253 AF050154 AF316398 AF316399 AF316401 AF316402 BC001779 BC006413 BC012134 BC017224 BC047528
GenPept AAC82342 AAC82343 AAD02504 AAH01779 AAH06413 AAH12134 AAH17224 AAH47528 AAL46624 AAL46625 AAL46626 AAL46627
ImmGen TOMM40 (murine)
RNA Seq Atlas 10452