Homo sapiens Gene: TOMM40

Summary
InnateDB Gene IDBG-56765.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol TOMM40
Gene Name translocase of outer mitochondrial membrane 40 homolog (yeast)
Synonyms C19orf1; D19S1177E; PER-EC1; PEREC1; TOM40
Species Homo sapiens
Ensembl Gene ENSG00000130204
Encoded Proteins
IDBP-56767 translocase of outer mitochondrial membrane 40 homolog (yeast)
IDBP-294347 translocase of outer mitochondrial membrane 40 homolog (yeast)
IDBP-381698 translocase of outer mitochondrial membrane 40 homolog (yeast)
IDBP-764163
IDBP-761787
IDBP-763822
IDBP-765049
Entrez Gene
Summary TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19: 45393826-45406946
Strand Forward strand
Band q13.32
Transcripts
ENST00000252487  ENSP00000252487
ENST00000405636  ENSP00000385184
ENST00000426677  ENSP00000410339
ENST00000592041  ENSP00000465608
ENST00000592434  ENSP00000466084
ENST00000589649  ENSP00000465032
ENST00000589253  ENSP00000465611
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein‑Protein  5
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0008308 voltage-gated anion channel activity
GO:0008320 protein transmembrane transporter activity
GO:0015288 porin activity
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0006820 anion transport
GO:0044070 regulation of anion transport
GO:0044267 cellular protein metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005742 mitochondrial outer membrane translocase complex
GO:0016021 integral to membrane
GO:0031307 integral to mitochondrial outer membrane
GO:0032592 integral to mitochondrial membrane
GO:0046930 pore complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000002984 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000001781 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_118595 Mitochondrial Protein Import
KEGG
hsa05014  Amyotrophic lateral sclerosis (ALS)
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O96008 
TrEMBL
UniProt Splice Variant
Entrez Gene 10452 
UniGene Hs.655909
RefSeq NM_001128916  NM_001128917  NM_006114 
HUGO 18001 
OMIM 608061
CCDS CCDS12646 
HPRD 16274
IMGT
EMBL AF043250 AF043251 AF043252 AF043253 AF050154 AF316398 AF316399 AF316401 AF316402 BC001779 BC006413 BC012134 BC017224 BC047528
GenPept AAC82342  AAC82343  AAD02504  AAH01779  AAH06413  AAH12134  AAH17224  AAH47528  AAL46624  AAL46625  AAL46626  AAL46627 
ImmGen TOMM40 (murine) 
RNA Seq Atlas 10452