InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOMM40

Summary

InnateDB Protein

IDBP-381698.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOMM40

Protein Name

translocase of outer mitochondrial membrane 40 homolog (yeast)

Synonyms

C19orf1; D19S1177E; PER-EC1; PEREC1; TOM40;

Species

Homo sapiens

Ensembl Protein

ENSP00000410339

InnateDB Gene

IDBG-56765 (TOMM40)

Protein Structure

UniProt Annotation

Function

Channel-forming protein essential for import of protein precursors into mitochondria. {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:15644312}; Multi-pass membrane protein {ECO:0000269PubMed:15644312}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008320	protein transmembrane transporter activity
GO:0015288	porin activity

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0006811	ion transport
GO:0044267	cellular protein metabolic process
GO:0055085	transmembrane transport
GO:0071806	protein transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005742	mitochondrial outer membrane translocase complex
GO:0016021	integral component of membrane
GO:0031307	integral component of mitochondrial outer membrane
GO:0032592	integral component of mitochondrial membrane
GO:0046930	pore complex
GO:0070062	extracellular vesicular exosome