Version 5.4
Homo sapiens Gene: HOXB4
Summary
InnateDB Gene IDBG-56810.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXB4
Gene Name homeobox B4
Synonyms HOX-2.6; HOX2; HOX2F
Species Homo sapiens
Ensembl Gene ENSG00000182742
Encoded Proteins
IDBP-56812
homeobox B4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48575513-48580111
Strand Reverse strand
Band q21.32
Transcripts
ENST00000332503 ENSP00000328928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 5 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002011 morphogenesis of an epithelial sheet
GO:0006351 transcription, DNA-templated
GO:0008283 cell proliferation
GO:0009952 anterior/posterior pattern specification
GO:0030097 hemopoiesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048103 somatic stem cell division
GO:0048536 spleen development
GO:0048539 bone marrow development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0060216 definitive hemopoiesis
GO:0060218 hematopoietic stem cell differentiation
GO:2000738 positive regulation of stem cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038692
View Gene Order
ENSBTAG00000039599
Not yet available
Cross-References
SwissProt P17483
TrEMBL
UniProt Splice Variant
Entrez Gene 3214
UniGene Hs.664706 Hs.730355
RefSeq NM_024015
HUGO HGNC:5115
OMIM 142965
CCDS CCDS11529
HPRD
IMGT
EMBL AF287967 AF307160 AL137449 BC049204 X16174
GenPept AAG31554 AAG45052 AAH49204 CAA34296 CAB70742
RNA Seq Atlas 3214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca