InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOXB4

Summary

InnateDB Protein

IDBP-56812.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXB4

Protein Name

homeobox B4

Synonyms

HOX-2.6; HOX2; HOX2F;

Species

Homo sapiens

Ensembl Protein

ENSP00000328928

InnateDB Gene

IDBG-56810 (HOXB4)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	5 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002011	morphogenesis of an epithelial sheet
GO:0006351	transcription, DNA-templated
GO:0008283	cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0030097	hemopoiesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048103	somatic stem cell division
GO:0048536	spleen development
GO:0048539	bone marrow development
GO:0048704	embryonic skeletal system morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0060216	definitive hemopoiesis
GO:0060218	hematopoietic stem cell differentiation
GO:2000738	positive regulation of stem cell differentiation