InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP6AP2

Summary

InnateDB Gene

IDBG-56836.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6AP2

Gene Name

ATPase, H+ transporting, lysosomal accessory protein 2

Synonyms

APT6M8-9; ATP6IP2; ATP6M8-9; ELDF10; M8-9; MRXE; MRXSH; MSTP009; PRR; RENR; XMRE; XPDS

Species

Homo sapiens

Ensembl Gene

ENSG00000182220

Encoded Proteins

IDBP-56838

ATPase, H+ transporting, lysosomal accessory protein 2

IDBP-367488

ATPase, H+ transporting, lysosomal accessory protein 2

IDBP-367489

ATPase, H+ transporting, lysosomal accessory protein 2

IDBP-367492

ATPase, H+ transporting, lysosomal accessory protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:40580908-40606637

Strand

Forward strand

Band

p11.4

Transcripts

ENST00000378438	ENSP00000367697
ENST00000436783	ENSP00000403969
ENST00000423649	ENSP00000410105
ENST00000447485	ENSP00000411317
ENST00000486558
ENST00000487051
ENST00000479120

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004190	aspartic-type endopeptidase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0002003	angiotensin maturation
GO:0006508	proteolysis
GO:0008152	metabolic process
GO:0008219	cell death
GO:0021903	rostrocaudal neural tube patterning
GO:0030177	positive regulation of Wnt signaling pathway
GO:0032914	positive regulation of transforming growth factor beta1 production
GO:0043408	regulation of MAPK cascade
GO:0044267	cellular protein metabolic process
GO:0048069	eye pigmentation
GO:0060323	head morphogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031007

View Gene Order

ENSBTAG00000017801

Not yet available

Pathways

NETPATH

REACTOME

REACT_147707

Metabolism of Angiotensinogen to Angiotensins pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

INOH

PID NCI

wnt_signaling_pathway

Wnt signaling network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.495960

RefSeq

NM_005765

HUGO

OMIM

CCDS

CCDS14252

HPRD

06454

IMGT

EMBL

GenPept

RNA Seq Atlas