InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp6ap2

Summary

InnateDB Gene

IDBG-132197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6ap2

Gene Name

ATPase, H+ transporting, lysosomal accessory protein 2

Synonyms

(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2; ATP6M8-9; M8-9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031007

Encoded Proteins

IDBP-132199

ATPase, H+ transporting, lysosomal accessory protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182220:
This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:12587801-12617049

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000033313	ENSMUSP00000033313
ENSMUST00000137277

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0002003	angiotensin maturation
GO:0006508	proteolysis
GO:0021903	rostrocaudal neural tube patterning
GO:0030177	positive regulation of Wnt signaling pathway
GO:0032914	positive regulation of transforming growth factor beta1 production
GO:0043408	regulation of MAPK cascade
GO:0048069	eye pigmentation
GO:0060323	head morphogenesis

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000182220

View Gene Order

ENSBTAG00000017801

Not yet available

Pathways

NETPATH

REACTOME

REACT_247926

Metabolism of proteins pathway

REACT_206913

Peptide hormone metabolism pathway

REACT_196539

Metabolism of Angiotensinogen to Angiotensins pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_147707

Metabolism of Angiotensinogen to Angiotensins pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

INOH

PID NCI

wnt_signaling_pathway

Wnt signaling network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.25148 Mm.399513

RefSeq

NM_027439

OMIM

CCDS

CCDS30023

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas