InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APOC1

Summary

InnateDB Gene

IDBG-56839.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOC1

Gene Name

apolipoprotein C-I

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000130208

Encoded Proteins

IDBP-765734

IDBP-761999

IDBP-760446

IDBP-763289

IDBP-765255

IDBP-764800

IDBP-765973

IDBP-761351

IDBP-763660

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:44914247-44919349

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000586638	ENSP00000466146
ENST00000588750	ENSP00000465356
ENST00000592176	ENSP00000466227
ENST00000589781	ENSP00000467504
ENST00000588802	ENSP00000468029
ENST00000589078	ENSP00000465710
ENST00000592535	ENSP00000468276
ENST00000592885	ENSP00000467368
ENST00000590334	ENSP00000465190

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005504	fatty acid binding
GO:0031210	phosphatidylcholine binding
GO:0055102	lipase inhibitor activity
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0008203	cholesterol metabolic process
GO:0010873	positive regulation of cholesterol esterification
GO:0010900	negative regulation of phosphatidylcholine catabolic process
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0032374	regulation of cholesterol transport
GO:0032375	negative regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034369	plasma lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034379	very-low-density lipoprotein particle assembly
GO:0034382	chylomicron remnant clearance
GO:0034447	very-low-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0043085	positive regulation of catalytic activity
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0050995	negative regulation of lipid catabolic process
GO:0051005	negative regulation of lipoprotein lipase activity

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.737668

RefSeq

NM_001645 XM_005258855

HUGO

OMIM

CCDS

CCDS12648

HPRD

00131

IMGT

EMBL

GenPept

RNA Seq Atlas