Version 5.4
Homo sapiens Protein: APOC1
Summary
InnateDB Protein IDBP-761999.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOC1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000465356
InnateDB Gene IDBG-56839 (APOC1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004859 phospholipase inhibitor activity
GO:0005504 fatty acid binding
GO:0031210 phosphatidylcholine binding
GO:0055102 lipase inhibitor activity
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0008203 cholesterol metabolic process
GO:0010873 positive regulation of cholesterol esterification
GO:0010900 negative regulation of phosphatidylcholine catabolic process
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0032374 regulation of cholesterol transport
GO:0032375 negative regulation of cholesterol transport
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034369 plasma lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034382 chylomicron remnant clearance
GO:0034447 very-low-density lipoprotein particle clearance
GO:0042157 lipoprotein metabolic process
GO:0043085 positive regulation of catalytic activity
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0045833 negative regulation of lipid metabolic process
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0050995 negative regulation of lipid catabolic process
GO:0051005 negative regulation of lipoprotein lipase activity
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006781 Apolipoprotein C-I
PFAM PF04691
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02654
PhosphoSite PhosphoSite-
TrEMBL K7ERI9
UniProt Splice Variant
Entrez Gene 341
UniGene Hs.737668
RefSeq NP_001636
HUGO HGNC:607
OMIM 107710
CCDS CCDS12648
HPRD 00131
IMGT
EMBL AC011481 AF050154 AK312036 AM392727 AY422954 BC009698 BC055093 BT007142 CH471126 CR456907 FJ525874 M20843 M20902 M27359 X00570
GenPept AAA51762 AAA51763 AAA88018 AAD02506 AAH09698 AAH55093 AAP35806 AAQ91813 ACN81312 BAG34973 CAA25235 CAG33188 CAL37605 EAW57307 EAW57308

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca