Version 5.4
Homo sapiens Gene: DPF2
Summary
InnateDB Gene IDBG-56871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPF2
Gene Name D4, zinc and double PHD fingers family 2
Synonyms REQ; ubi-d4; UBID4
Species Homo sapiens
Ensembl Gene ENSG00000133884
Encoded Proteins
IDBP-56873
D4, zinc and double PHD fingers family 2
IDBP-378268
D4, zinc and double PHD fingers family 2
IDBP-591594
D4, zinc and double PHD fingers family 2
IDBP-587342
D4, zinc and double PHD fingers family 2
IDBP-590251
D4, zinc and double PHD fingers family 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65333754-65353249
Strand Forward strand
Band q13.1
Transcripts
ENST00000252268 ENSP00000252268
ENST00000415073 ENSP00000399714
ENST00000444314
ENST00000528416 ENSP00000436901
ENST00000530993
ENST00000524666
ENST00000532264
ENST00000532102 ENSP00000434885
ENST00000530973
ENST00000532492
ENST00000532052
ENST00000531989 ENSP00000435887
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 53 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024826
View Gene Order
ENSBTAG00000003077
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.13495
RefSeq NM_006268 XM_005274149
HUGO
OMIM
CCDS CCDS8100
HPRD 03394
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca