InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPF2

Summary

InnateDB Protein

IDBP-591594.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPF2

Protein Name

D4, zinc and double PHD fingers family 2

Synonyms

REQ; ubi-d4; UBID4;

Species

Homo sapiens

Ensembl Protein

ENSP00000436901

InnateDB Gene

IDBG-56871 (DPF2)

Protein Structure

UniProt Annotation

Function

May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

Subcellular Localization

Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR007087 Zinc finger, C2H2
IPR011011 Zinc finger, FYVE/PHD-type
IPR015880 Zinc finger, C2H2-like
IPR019787 Zinc finger, PHD-finger

PFAM

PF00096
PF00628

PRINTS

PIRSF

SMART

SM00249
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92785