Version 5.4
Homo sapiens Gene: HOXB9
Summary
InnateDB Gene IDBG-56983.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXB9
Gene Name homeobox B9
Synonyms HOX-2.5; HOX2; HOX2E
Species Homo sapiens
Ensembl Gene ENSG00000170689
Encoded Proteins
IDBP-56985
homeobox B9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48621159-48626356
Strand Reverse strand
Band q21.32
Transcripts
ENST00000311177 ENSP00000309439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0030879 mammary gland development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048706 embryonic skeletal system development
GO:0060070 canonical Wnt signaling pathway
GO:0060326 cell chemotaxis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020875
View Gene Order
ENSBTAG00000025009
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P17482
TrEMBL
UniProt Splice Variant
Entrez Gene 3219
UniGene Hs.463350
RefSeq NM_024017
HUGO HGNC:5120
OMIM 142964
CCDS CCDS11534
HPRD
IMGT
EMBL AK315480 AY014295 AY014296 BC015565 CH471109 X16172
GenPept AAG42144 AAH15565 BAG37864 CAA34294 EAW94721
RNA Seq Atlas 3219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca