InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TF

Summary

InnateDB Gene

IDBG-57280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

transferrin

Synonyms

PRO1557; PRO2086; TFQTL1

Species

Homo sapiens

Ensembl Gene

ENSG00000091513

Encoded Proteins

IDBP-294481

transferrin

IDBP-384270

transferrin

IDBP-476567

transferrin

IDBP-482041

transferrin

IDBP-477216

transferrin

IDBP-485050

transferrin

IDBP-484423

transferrin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:133745956-133779006

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000402696	ENSP00000385834
ENST00000414694	ENSP00000401505
ENST00000466911	ENSP00000417468
ENST00000474287
ENST00000482271	ENSP00000419338
ENST00000460531
ENST00000485977	ENSP00000418716
ENST00000494430	ENSP00000418396
ENST00000493011
ENST00000475382
ENST00000498622
ENST00000461695	ENSP00000419714
ENST00000462495
ENST00000467842

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008199	ferric iron binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001895	retina homeostasis
GO:0002576	platelet degranulation
GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0033572	transferrin transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005905	coated pit
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0034774	secretory granule lumen
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle