InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trf

Summary

InnateDB Gene

IDBG-194237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trf

Gene Name

transferrin

Synonyms

AI266983; Cd176; HP; hpx; Tf; Tfn

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032554

Encoded Proteins

IDBP-194239

transferrin

IDBP-255246

transferrin

IDBP-538658

transferrin

IDBP-624576

transferrin

IDBP-624578

transferrin

IDBP-624582

transferrin

IDBP-624585

transferrin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091513:
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:103204001-103230444

Strand

Reverse strand

Band

Transcripts

ENSMUST00000035158	ENSMUSP00000035158
ENSMUST00000112645	ENSMUSP00000108264
ENSMUST00000112503
ENSMUST00000126359	ENSMUSP00000120472
ENSMUST00000168142	ENSMUSP00000128609
ENSMUST00000170904	ENSMUSP00000128390
ENSMUST00000164377	ENSMUSP00000128647
ENSMUST00000165296	ENSMUSP00000129013
ENSMUST00000190051

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008199	ferric iron binding

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0007015	actin filament organization
GO:0007257	activation of JUN kinase activity
GO:0030316	osteoclast differentiation
GO:0042327	positive regulation of phosphorylation
GO:0045780	positive regulation of bone resorption
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060395	SMAD protein signal transduction
GO:0070371	ERK1 and ERK2 cascade
GO:2000147	positive regulation of cell motility

Cellular Component

GO:0005576	extracellular region
GO:0005768	endosome
GO:0005769	early endosome
GO:0005905	coated pit
GO:0030120	vesicle coat
GO:0030139	endocytic vesicle
GO:0055037	recycling endosome
GO:0097433	dense body