Version 5.4
Homo sapiens Gene: GABRP
Summary
InnateDB Gene IDBG-57350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRP
Gene Name gamma-aminobutyric acid (GABA) A receptor, pi
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000094755
Encoded Proteins
IDBP-57352
gamma-aminobutyric acid (GABA) A receptor, pi
IDBP-480425
gamma-aminobutyric acid (GABA) A receptor, pi
IDBP-481016
gamma-aminobutyric acid (GABA) A receptor, pi
IDBP-481005
gamma-aminobutyric acid (GABA) A receptor, pi
IDBP-478138
gamma-aminobutyric acid (GABA) A receptor, pi
IDBP-476660
gamma-aminobutyric acid (GABA) A receptor, pi
IDBP-482293
gamma-aminobutyric acid (GABA) A receptor, pi
IDBP-477894
gamma-aminobutyric acid (GABA) A receptor, pi
IDBP-474183
gamma-aminobutyric acid (GABA) A receptor, pi
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. [provided by RefSeq, Jul 2008]
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:170763350-170814047
Strand Forward strand
Band q35.1
Transcripts
ENST00000265294 ENSP00000265294
ENST00000521481 ENSP00000428804
ENST00000521009 ENSP00000428103
ENST00000519196 ENSP00000429668
ENST00000522868 ENSP00000430188
ENST00000518525 ENSP00000430100
ENST00000518122 ENSP00000429815
ENST00000519385 ENSP00000430727
ENST00000519598 ENSP00000430772
ENST00000519137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0034220 ion transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020159
View Gene Order
ENSBTAG00000002779
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.26225
RefSeq NM_001291985 NM_014211 XM_005265872 XM_005265873
HUGO
OMIM
CCDS CCDS4375 CCDS75368
HPRD 04105
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca