Version 5.4
Homo sapiens Protein: GABRP
Summary
InnateDB Protein IDBP-57352.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRP
Protein Name gamma-aminobutyric acid (GABA) A receptor, pi
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265294
InnateDB Gene IDBG-57350 (GABRP)
Protein Structure
UniProt Annotation
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Most abundant in the uterus, also expressed in lung, thymus and prostate.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0034220 ion transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008100 Gamma-aminobutyric-acid A receptor pi subunit
PFAM PF02932
PF02931
PRINTS PR00253
PR00252
PR01724
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00591
PhosphoSite PhosphoSite-O00591
TrEMBL E5RK74
UniProt Splice Variant
Entrez Gene 2568
UniGene Hs.26225
RefSeq NP_055026
HUGO HGNC:4089
OMIM 602729
CCDS CCDS4375
HPRD 04105
IMGT
EMBL AC008514 AF009694 AF009695 AF009696 AF009697 AF009698 AF009699 AF009700 AF009701 AF009702 AK292901 BC074810 BC074865 BC109105 BC109106 CH471062 U95367
GenPept AAC24194 AAC51357 AAH74810 AAH74865 AAI09106 AAI09107 BAF85590 EAW61467 EAW61468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca