Version 5.4
Homo sapiens Gene: AMOTL2
Summary
InnateDB Gene IDBG-57528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMOTL2
Gene Name angiomotin like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000114019
Encoded Proteins
IDBP-57532
angiomotin like 2
IDBP-384297
angiomotin like 2
IDBP-485387
angiomotin like 2
IDBP-473476
angiomotin like 2
IDBP-480019
angiomotin like 2
IDBP-481527
angiomotin like 2
IDBP-479184
angiomotin like 2
IDBP-478022
angiomotin like 2
IDBP-480881
angiomotin like 2
IDBP-476269
angiomotin like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:134355874-134375479
Strand Reverse strand
Band q22.2
Transcripts
ENST00000249883 ENSP00000249883
ENST00000422605 ENSP00000409999
ENST00000514516 ENSP00000424765
ENST00000506326
ENST00000513145 ENSP00000425475
ENST00000512955
ENST00000511759
ENST00000510560 ENSP00000427184
ENST00000504234 ENSP00000424910
ENST00000505596 ENSP00000427292
ENST00000506107 ENSP00000422658
ENST00000515172 ENSP00000427482
ENST00000502491 ENSP00000421521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0035329 hippo signaling
Cellular Component
GO:0005829 cytosol
GO:0005923 tight junction
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0055037 recycling endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032531
View Gene Order
ENSBTAG00000000742
Not yet available
Pathways
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.426312
RefSeq NM_001278683 NM_001278685 NM_016201 XM_005247520 XM_006713654 XM_006713655
HUGO
OMIM
CCDS CCDS33860 CCDS63783 CCDS63784
HPRD 16485
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca