Version 5.4
Homo sapiens Protein: AMOTL2
Summary
InnateDB Protein IDBP-384297.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMOTL2
Protein Name angiomotin like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000409999
InnateDB Gene IDBG-57528 (AMOTL2)
Protein Structure
UniProt Annotation
Function Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. {ECO:0000269PubMed:17293535, ECO:0000269PubMed:21937427, ECO:0000269PubMed:22362771}.
Subcellular Localization Recycling endosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0035329 hippo signaling
Cellular Component
GO:0005829 cytosol
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro IPR009114 Angiomotin
IPR024646 Angiomotin, C-terminal
PFAM PF12240
PRINTS PR01807
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2J4
PhosphoSite PhosphoSite-Q9Y2J4
TrEMBL D6RJA4
UniProt Splice Variant
Entrez Gene 51421
UniGene Hs.426312
RefSeq XP_006713718
HUGO HGNC:17812
OMIM 614658
CCDS
HPRD 16485
IMGT
EMBL AB023206 AC010207 AF175966 AK223598 AK291616 AK299270 BC011454
GenPept AAD56361 AAH11454 BAA76833 BAD97318 BAF84305 BAH12987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca