Version 5.4
Homo sapiens Gene: POLE2
Summary
InnateDB Gene IDBG-5761.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLE2
Gene Name polymerase (DNA directed), epsilon 2, accessory subunit
Synonyms DPE2
Species Homo sapiens
Ensembl Gene ENSG00000100479
Encoded Proteins
IDBP-5763
polymerase (DNA directed), epsilon 2 (p59 subunit)
IDBP-583387
polymerase (DNA directed), epsilon 2 (p59 subunit)
IDBP-599969
polymerase (DNA directed), epsilon 2 (p59 subunit)
IDBP-806769
polymerase (DNA directed), epsilon 2, accessory subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:49643555-49688422
Strand Reverse strand
Band q21.3
Transcripts
ENST00000216367 ENSP00000216367
ENST00000554851
ENST00000556937
ENST00000554671
ENST00000555724
ENST00000539565 ENSP00000446313
ENST00000556584
ENST00000554377
ENST00000554396 ENSP00000451621
ENST00000553850
ENST00000553805 ENSP00000475468
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006270 DNA replication initiation
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0032201 telomere maintenance via semi-conservative replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0008622 epsilon DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020974
View Gene Order
ENSBTAG00000004931
Not yet available
Pathways
NETPATH
REACTOME
REACT_7993
Telomere C-strand synthesis initiation pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_2244
DNA replication initiation pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_8030
Extension of Telomeres pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
hsa03420
Nucleotide excision repair pathway
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt P56282
TrEMBL Q86SY9 U3KQ22
UniProt Splice Variant
Entrez Gene 5427
UniGene Hs.162777
RefSeq NM_001197330 NM_001197331 NM_002692
HUGO HGNC:9178
OMIM 602670
CCDS CCDS32073 CCDS55914 CCDS55915
HPRD
IMGT
EMBL AF025840 AF036899 AF387021 AF387022 AF387023 AF387024 AF387025 AF387026 AF387027 AF387028 AF387029 AF387030 AF387031 AF387032 AF387033 AF387034 AK293163 AL139099 AL591767 BC112962 BC126218 BC126220 BX248064 EF506887
GenPept AAC39610 AAC51920 AAI12963 AAI26219 AAI26221 AAK72254 ABO43040 BAG56707 CAD62358
RNA Seq Atlas 5427

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca