Version 5.4
Homo sapiens Protein: POLE2
Summary
InnateDB Protein IDBP-583387.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLE2
Protein Name polymerase (DNA directed), epsilon 2 (p59 subunit)
Synonyms DPE2;
Species Homo sapiens
Ensembl Protein ENSP00000446313
InnateDB Gene IDBG-5761 (POLE2)
Protein Structure
UniProt Annotation
Function Participates in DNA repair and in chromosomal DNA replication.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006270 DNA replication initiation
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0032201 telomere maintenance via semi-conservative replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0008622 epsilon DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR007185 DNA polymerase alpha/epsilon, subunit B
IPR016266 DNA polymerase epsilon, subunit B
IPR024639 DNA polymerase epsilon subunit B, N-terminal
PFAM PF04042
PF12213
PRINTS
PIRSF PIRSF000799
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56282
PhosphoSite PhosphoSite-P56282
TrEMBL Q86SY9
UniProt Splice Variant
Entrez Gene 5427
UniGene Hs.162777
RefSeq NP_001184259
HUGO HGNC:9178
OMIM 602670
CCDS CCDS55914
HPRD 16007
IMGT
EMBL AF025840 AF036899 AF387021 AF387022 AF387023 AF387024 AF387025 AF387026 AF387027 AF387028 AF387029 AF387030 AF387031 AF387032 AF387033 AF387034 AK293163 AL139099 AL591767 BC112962 BC126218 BC126220 BX248064 EF506887
GenPept AAC39610 AAC51920 AAI12963 AAI26219 AAI26221 AAK72254 ABO43040 BAG56707 CAD62358

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca