InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NGFR

Summary

InnateDB Gene

IDBG-57653.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NGFR

Gene Name

nerve growth factor receptor

Synonyms

CD271; Gp80-LNGFR; p75(NTR); p75NTR; TNFRSF16

Species

Homo sapiens

Ensembl Gene

ENSG00000064300

Encoded Proteins

IDBP-57655

nerve growth factor receptor

IDBP-475545

nerve growth factor receptor

IDBP-474446

nerve growth factor receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:49495293-49515017

Strand

Forward strand

Band

q21.33

Transcripts

ENST00000172229	ENSP00000172229
ENST00000509200	ENSP00000421514
ENST00000504201	ENSP00000421731

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	74 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005035	death receptor activity
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0031625	ubiquitin protein ligase binding
GO:0048406	nerve growth factor binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0010468	regulation of gene expression
GO:0012501	programmed cell death
GO:0016048	detection of temperature stimulus
GO:0021675	nerve development
GO:0031069	hair follicle morphogenesis
GO:0031293	membrane protein intracellular domain proteolysis
GO:0032922	circadian regulation of gene expression
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042488	positive regulation of odontogenesis of dentin-containing tooth
GO:0042593	glucose homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588	skin development
GO:0045786	negative regulation of cell cycle
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048146	positive regulation of fibroblast proliferation
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis
GO:0050772	positive regulation of axonogenesis
GO:0051799	negative regulation of hair follicle development
GO:0097190	apoptotic signaling pathway
GO:2001235	positive regulation of apoptotic signaling pathway
GO:2001273	regulation of glucose import in response to insulin stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0097481	neuronal postsynaptic density