InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ngfr

Summary

InnateDB Gene

IDBG-209608.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ngfr

Gene Name

nerve growth factor receptor (TNFR superfamily, member 16)

Synonyms

LNGFR; p75; p75NGFR; p75NTR; Tnfrsf16

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000120

Encoded Proteins

IDBP-209610

nerve growth factor receptor (TNFR superfamily, member 16)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064300:
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:95568818-95587735

Strand

Reverse strand

Band

Transcripts

ENSMUST00000000122

ENSMUSP00000000122

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005035	death receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0048406	nerve growth factor binding

Biological Process

GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0010468	regulation of gene expression
GO:0012501	programmed cell death
GO:0016048	detection of temperature stimulus
GO:0021675	nerve development
GO:0031069	hair follicle morphogenesis
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042488	positive regulation of odontogenesis of dentin-containing tooth
GO:0043588	skin development
GO:0048146	positive regulation of fibroblast proliferation
GO:0051799	negative regulation of hair follicle development
GO:2001235	positive regulation of apoptotic signaling pathway