Version 5.4
Homo sapiens Gene: MEIS2
Summary
InnateDB Gene IDBG-5800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEIS2
Gene Name Meis homeobox 2
Synonyms HsT18361; MRG1
Species Homo sapiens
Ensembl Gene ENSG00000134138
Encoded Proteins
IDBP-5802
Meis homeobox 2
IDBP-5808
Meis homeobox 2
IDBP-5810
Meis homeobox 2
IDBP-234908
Meis homeobox 2
IDBP-234910
Meis homeobox 2
IDBP-365173
Meis homeobox 2
IDBP-589557
Meis homeobox 2
IDBP-590886
Meis homeobox 2
IDBP-603291
Meis homeobox 2
IDBP-584359
Meis homeobox 2
IDBP-586924
Meis homeobox 2
IDBP-583752
Meis homeobox 2
IDBP-583351
Meis homeobox 2
IDBP-602618
Meis homeobox 2
IDBP-812514
Meis homeobox 2
IDBP-812516
Meis homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a homeobox protein belonging to the TALE (\'three amino acid loop extension\') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:36889204-37101299
Strand Reverse strand
Band q14
Transcripts
ENST00000340545 ENSP00000339549
ENST00000314177 ENSP00000326296
ENST00000338564 ENSP00000341400
ENST00000397624 ENSP00000380749
ENST00000397620 ENSP00000380745
ENST00000424352 ENSP00000404185
ENST00000561208 ENSP00000453793
ENST00000560702
ENST00000559085 ENSP00000453390
ENST00000560570 ENSP00000453481
ENST00000559972
ENST00000561264
ENST00000561284
ENST00000559371
ENST00000557992
ENST00000558643
ENST00000559561 ENSP00000453497
ENST00000559408
ENST00000561163
ENST00000561422
ENST00000557796 ENSP00000452693
ENST00000560617 ENSP00000452874
ENST00000560697 ENSP00000452770
ENST00000558313 ENSP00000453782
ENST00000559129
ENST00000607277 ENSP00000475899
ENST00000606653 ENSP00000475660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001654 eye development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0009612 response to mechanical stimulus
GO:0031016 pancreas development
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070848 response to growth factor
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027210
View Gene Order
ENSBTAG00000003172
Not yet available
Cross-References
SwissProt
TrEMBL H0YKE5 H0YKN2
UniProt Splice Variant
Entrez Gene 4212
UniGene Hs.540345
RefSeq NM_001220482 NM_002399 NM_170674 NM_170675 NM_170676 NM_170677 NM_172315 NM_172316 XM_006720522 XM_006720523 XM_006720524 XM_006720525 XM_006720529
HUGO HGNC:7001
OMIM 601740
CCDS CCDS10044 CCDS10045 CCDS42014 CCDS45217 CCDS45218 CCDS45219 CCDS45220
HPRD 03443
IMGT
EMBL AC018563 AC069483 AC078909
GenPept
RNA Seq Atlas 4212

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca