InnateDB Protein
|
IDBP-5808.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MEIS2
|
Protein Name
|
Meis homeobox 2
|
Synonyms
|
HsT18361; MRG1;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000326296
|
InnateDB Gene
|
IDBG-5800 (MEIS2)
|
Protein Structure
|
|
Function |
Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription. {ECO:0000269PubMed:10764806, ECO:0000269PubMed:11279116, ECO:0000269PubMed:21746878}.
|
Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
11
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
12 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000978
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding
|
GO:0001077
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0003712
|
transcription cofactor activity
|
GO:0003714
|
transcription corepressor activity
|
GO:0005515
|
protein binding
|
GO:0008134
|
transcription factor binding
|
GO:0043565
|
sequence-specific DNA binding
|
|
Biological Process |
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
GO:0006366
|
transcription from RNA polymerase II promoter
|
GO:0045638
|
negative regulation of myeloid cell differentiation
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O14770
|
PhosphoSite |
PhosphoSite-O14770
|
TrEMBL |
H0YKN2
|
UniProt Splice Variant |
|
Entrez Gene |
4212
|
UniGene |
Hs.540345
|
RefSeq |
|
HUGO |
HGNC:7001
|
OMIM |
601740
|
CCDS |
|
HPRD |
03443
|
IMGT |
|
EMBL |
AC018563
AC069483
AC078909
AF017418
AF178948
AF179896
AF179897
AF179898
AF179899
AK056038
AK056620
BC001516
BC001844
BC007202
BC050431
CH471125
|
GenPept |
AAB70270
AAF81638
AAF81639
AAF81640
AAF81641
AAF81642
AAH01516
AAH01844
AAH07202
AAH50431
BAG51610
BAG51768
EAW92352
EAW92353
EAW92354
EAW92356
EAW92357
|
|
|