Version 5.4
Homo sapiens Gene: SART1
Summary
InnateDB Gene IDBG-58125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SART1
Gene Name squamous cell carcinoma antigen recognized by T cells
Synonyms Ara1; HOMS1; SART1259; SNRNP110; Snu66
Species Homo sapiens
Ensembl Gene ENSG00000175467
Encoded Proteins
IDBP-58127
squamous cell carcinoma antigen recognized by T cells
IDBP-592857
squamous cell carcinoma antigen recognized by T cells
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65961689-65979828
Strand Forward strand
Band q13.1
Transcripts
ENST00000312397 ENSP00000310448
ENST00000532333
ENST00000529532
ENST00000528573
ENST00000530251 ENSP00000436218
ENST00000533386
ENST00000529580
ENST00000528137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 114 experimentally validated interaction(s) in this database.
Experimentally validated
Total 114 [view]
Protein-Protein 114 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0007050 cell cycle arrest
GO:0045585 positive regulation of cytotoxic T cell differentiation
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039148
View Gene Order
ENSBTAG00000003094
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502883 Hs.618087
RefSeq NM_005146
HUGO
OMIM
CCDS CCDS31611
HPRD 10440
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca