Version 5.4
Bos taurus Gene: SART1
Summary
InnateDB Gene IDBG-644324.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SART1
Gene Name U4/U6.U5 tri-snRNP-associated protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003094
Encoded Proteins
IDBP-696960
squamous cell carcinoma antigen recognized by T cells
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175467:
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:44726692-44741763
Strand Forward strand
Band
Transcripts
ENSBTAT00000004027 ENSBTAP00000004027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.
Predicted by orthology
Total 70 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0045585 positive regulation of cytotoxic T cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0015030 Cajal body
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000175467
View Gene Order
ENSMUSG00000039148
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
mmu03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MZ21 Q27HF2
UniProt Splice Variant
Entrez Gene 615704
UniGene Bt.60607 Bt.90709
RefSeq NM_001193086
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02063574 DQ404153
GenPept ABD57203
RNA Seq Atlas 615704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca