InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SYMPK

Summary

InnateDB Gene

IDBG-58156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYMPK

Gene Name

symplekin

Synonyms

SPK; SYM

Species

Homo sapiens

Ensembl Gene

ENSG00000125755

Encoded Proteins

IDBP-58158

symplekin

IDBP-764377

IDBP-765084

IDBP-813714

symplekin

IDBP-765848

IDBP-765936

IDBP-766114

IDBP-762224

IDBP-813715

symplekin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3\'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:45815410-45863290

Strand

Reverse strand

Band

q13.32

Transcripts

ENST00000245934	ENSP00000245934
ENST00000601582
ENST00000596824	ENSP00000470957
ENST00000593899
ENST00000598059	ENSP00000471694
ENST00000596518
ENST00000599460	ENSP00000479480
ENST00000598364
ENST00000594293	ENSP00000471770
ENST00000602061	ENSP00000469296
ENST00000593504
ENST00000600237	ENSP00000473136
ENST00000601600	ENSP00000470977
ENST00000598896
ENST00000593959
ENST00000598155
ENST00000599814	ENSP00000478599
ENST00000598329

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006378	mRNA polyadenylation
GO:0007155	cell adhesion
GO:0035307	positive regulation of protein dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005923	tight junction

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023118

View Gene Order

ENSBTAG00000012101

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04530

Tight junction pathway

hsa03015

mRNA surveillance pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.515475

RefSeq

NM_004819 XM_005259286

HUGO

OMIM

CCDS

CCDS12676

HPRD

09090

IMGT

EMBL

GenPept

RNA Seq Atlas