InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sympk

Summary

InnateDB Gene

IDBG-149105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sympk

Gene Name

symplekin

Synonyms

1500016F02Rik; 4632415H16Rik; AA125406; AI449890; SPK; SYM

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023118

Encoded Proteins

IDBP-149107

symplekin

IDBP-535273

symplekin

IDBP-789721

symplekin

IDBP-541195

symplekin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125755:
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3\'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19024377-19054618

Strand

Forward strand

Band

Transcripts

ENSMUST00000023882	ENSMUSP00000023882
ENSMUST00000153976	ENSMUSP00000121540
ENSMUST00000137287
ENSMUST00000146903	ENSMUSP00000138740
ENSMUST00000138440
ENSMUST00000148861
ENSMUST00000130328	ENSMUSP00000115900
ENSMUST00000131230

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006378	mRNA polyadenylation
GO:0007155	cell adhesion
GO:0035307	positive regulation of protein dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005923	tight junction

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000125755

View Gene Order

ENSBTAG00000012101

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04530

Tight junction pathway

mmu03015

mRNA surveillance pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04530

Tight junction pathway

hsa03015

mRNA surveillance pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.130902

RefSeq

NM_026605 XM_006540331 XM_006540332

OMIM

CCDS

CCDS52051

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas