Version 5.4
Homo sapiens Gene: GCFC2
Summary
InnateDB Gene IDBG-58226.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCFC2
Gene Name GC-rich sequence DNA-binding factor 2
Synonyms C2orf3; DNABF; GCF; TCF9
Species Homo sapiens
Ensembl Gene ENSG00000005436
Encoded Proteins
IDBP-58230
chromosome 2 open reading frame 3
IDBP-295451
chromosome 2 open reading frame 3
IDBP-381096
chromosome 2 open reading frame 3
IDBP-381098
chromosome 2 open reading frame 3
IDBP-806427
GC-rich sequence DNA-binding factor 2
IDBP-806506
GC-rich sequence DNA-binding factor 2
IDBP-806512
GC-rich sequence DNA-binding factor 2
IDBP-806515
GC-rich sequence DNA-binding factor 2
IDBP-595699
chromosome 2 open reading frame 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:75652000-75710989
Strand Reverse strand
Band p12
Transcripts
ENST00000321027 ENSP00000318690
ENST00000409857 ENSP00000386552
ENST00000427862 ENSP00000409340
ENST00000442309 ENSP00000415831
ENST00000470285 ENSP00000475130
ENST00000470197
ENST00000492826 ENSP00000475108
ENST00000472230 ENSP00000474136
ENST00000486016
ENST00000470503 ENSP00000474481
ENST00000541687 ENSP00000437767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000245 spliceosomal complex assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0071008 U2-type post-mRNA release spliceosomal complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035125
View Gene Order
ENSBTAG00000008048
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.303808 Hs.658579 Hs.710597 Hs.734364
RefSeq NM_001201334 NM_001201335 NM_003203
HUGO
OMIM
CCDS CCDS1961 CCDS62943
HPRD 01791
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca