Version 5.4
Homo sapiens Protein: GCFC2
Summary
InnateDB Protein IDBP-295451.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCFC2
Protein Name chromosome 2 open reading frame 3
Synonyms C2orf3; DNABF; GCF; TCF9;
Species Homo sapiens
Ensembl Protein ENSP00000386552
InnateDB Gene IDBG-58226 (GCFC2)
Protein Structure
UniProt Annotation
Function Factor that represses transcription. It binds to the GC- rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons. {ECO:0000269PubMed:24304693}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000269PubMed:24304693}. Nucleus, nucleolus {ECO:0000269PubMed:24304693}.
Disease Associations
Tissue Specificity Widely expressed in tissues and cell lines.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000245 spliceosomal complex assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0071008 U2-type post-mRNA release spliceosomal complex
Protein Structure and Domains
PDB ID
InterPro IPR022783 GC-rich sequence DNA-binding factor domain
PFAM PF07842
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P16383
PhosphoSite PhosphoSite-P16383
TrEMBL A4UHR0
UniProt Splice Variant
Entrez Gene 6936
UniGene Hs.734364
RefSeq
HUGO HGNC:1317
OMIM 189901
CCDS
HPRD 01791
IMGT
EMBL AC005034 BC064559 CH471053 EF158467 EF158469 M29204
GenPept AAA35598 AAH64559 AAY14973 ABO84856 ABO84858 EAW99586

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca