Version 5.4
Homo sapiens Gene: CST6
Summary
InnateDB Gene IDBG-58241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST6
Gene Name cystatin E/M
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000175315
Encoded Proteins
IDBP-58243
cystatin E/M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66011841-66013505
Strand Forward strand
Band q13.1
Transcripts
ENST00000312134 ENSP00000311313
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0008544 epidermis development
GO:0009653 anatomical structure morphogenesis
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0001533 cornified envelope
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000024846
View Gene Order
Cross-References
SwissProt Q15828
TrEMBL
UniProt Splice Variant
Entrez Gene 1474
UniGene
RefSeq NM_001323
HUGO HGNC:2478
OMIM 601891
CCDS CCDS8126
HPRD
IMGT
EMBL AY145051 BC031334 U62800 U81233
GenPept AAB06566 AAB61305 AAH31334 AAN52757
RNA Seq Atlas 1474

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca