Version 5.4
Homo sapiens Protein: CST6
Summary
InnateDB Protein IDBP-58243.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST6
Protein Name cystatin E/M
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000311313
InnateDB Gene IDBG-58241 (CST6)
Protein Structure
UniProt Annotation
Function Shows moderate inhibition of cathepsin B but is not active against cathepsin C.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity. {ECO:0000269PubMed:11348457}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0008544 epidermis development
GO:0009653 anatomical structure morphogenesis
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0001533 cornified envelope
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15828
PhosphoSite PhosphoSite-Q15828
TrEMBL
UniProt Splice Variant
Entrez Gene 1474
UniGene
RefSeq NP_001314
HUGO HGNC:2478
OMIM 601891
CCDS CCDS8126
HPRD 03535
IMGT
EMBL AY145051 BC031334 U62800 U81233
GenPept AAB06566 AAB61305 AAH31334 AAN52757

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca