Version 5.4
Homo sapiens Gene: TRDMT1
Summary
InnateDB Gene IDBG-58327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRDMT1
Gene Name tRNA aspartic acid methyltransferase 1
Synonyms DMNT2; DNMT2; MHSAIIP; PUMET; RNMT1
Species Homo sapiens
Ensembl Gene ENSG00000107614
Encoded Proteins
IDBP-58329
tRNA aspartic acid methyltransferase 1
IDBP-58331
tRNA aspartic acid methyltransferase 1
IDBP-58335
tRNA aspartic acid methyltransferase 1
IDBP-367908
tRNA aspartic acid methyltransferase 1
IDBP-367911
tRNA aspartic acid methyltransferase 1
IDBP-476803
tRNA aspartic acid methyltransferase 1
IDBP-484797
tRNA aspartic acid methyltransferase 1
IDBP-588902
tRNA aspartic acid methyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:17142254-17202054
Strand Reverse strand
Band p13
Transcripts
ENST00000354631 ENSP00000346652
ENST00000377799 ENSP00000367030
ENST00000313936 ENSP00000324263
ENST00000452380
ENST00000436968 ENSP00000390611
ENST00000424636 ENSP00000389497
ENST00000451253
ENST00000495022 ENSP00000417594
ENST00000488990 ENSP00000419625
ENST00000486947
ENST00000479046
ENST00000525762 ENSP00000431476
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
Biological Process
GO:0001975 response to amphetamine
GO:0006306 DNA methylation
GO:0030488 tRNA methylation
GO:0090116 C-5 methylation of cytosine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026723
View Gene Order
ENSBTAG00000020546
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.351665
RefSeq NM_004412 XM_005252376
HUGO
OMIM
CCDS CCDS7114
HPRD 16001
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca