Version 5.4
Homo sapiens Protein: TRDMT1
Summary
InnateDB Protein IDBP-58331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRDMT1
Protein Name tRNA aspartic acid methyltransferase 1
Synonyms DMNT2; DNMT2; MHSAIIP; PUMET; RNMT1;
Species Homo sapiens
Ensembl Protein ENSP00000367030
InnateDB Gene IDBG-58327 (TRDMT1)
Protein Structure
UniProt Annotation
Function Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). {ECO:0000269PubMed:16424344}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
Biological Process
GO:0001975 response to amphetamine
GO:0030488 tRNA methylation
GO:0090116 C-5 methylation of cytosine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001525 C-5 cytosine methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF00145
PRINTS PR00105
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14717
PhosphoSite PhosphoSite-O14717
TrEMBL Q6ICS7
UniProt Splice Variant
Entrez Gene 1787
UniGene Hs.351665
RefSeq NP_004403
HUGO HGNC:2977
OMIM 602478
CCDS CCDS7114
HPRD 16001
IMGT
EMBL AC067747 AF012128 AF045888 AF329940 AF329941 AF329942 AF329943 AF329944 AJ223333 AK291417 AL133415 BC047733 CH471072 CR450316 EF444974
GenPept AAC39764 AAC51939 AAH47733 AAK68033 AAK68034 AAK68035 AAK68036 AAK68037 ACA05980 ACA05983 ACA05984 ACA05985 ACA05986 ACA05987 BAF84106 CAA11272 CAB87964 CAG29312 EAW86217 EAW86218 EAW86219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca