Version 5.4
Homo sapiens Gene: GAL3ST3
Summary
InnateDB Gene IDBG-58350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAL3ST3
Gene Name galactose-3-O-sulfotransferase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000175229
Encoded Proteins
IDBP-58352
galactose-3-O-sulfotransferase 3
IDBP-590327
galactose-3-O-sulfotransferase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66041952-66049180
Strand Reverse strand
Band q13.1
Transcripts
ENST00000312006 ENSP00000308591
ENST00000527878 ENSP00000434829
ENST00000527048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001733 galactosylceramide sulfotransferase activity
GO:0030246 carbohydrate binding
GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding
GO:0050694 galactose 3-O-sulfotransferase activity
GO:0050698 proteoglycan sulfotransferase activity
Biological Process
GO:0005996 monosaccharide metabolic process
GO:0006790 sulfur compound metabolic process
GO:0009058 biosynthetic process
GO:0009311 oligosaccharide metabolic process
GO:0030166 proteoglycan biosynthetic process
GO:0030309 poly-N-acetyllactosamine metabolic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047658
View Gene Order
ENSBTAG00000002772
Not yet available
Cross-References
SwissProt Q96A11
TrEMBL
UniProt Splice Variant
Entrez Gene 89792
UniGene Hs.208343
RefSeq NM_033036
HUGO HGNC:24144
OMIM 608234
CCDS CCDS8128
HPRD 10501
IMGT
EMBL AB053232 AY026481 BC113552 BC113554
GenPept AAI13553 AAI13555 AAK01945 BAB61900
RNA Seq Atlas 89792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca