InnateDB Protein
|
IDBP-590327.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
GAL3ST3
|
Protein Name
|
galactose-3-O-sulfotransferase 3
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000434829
|
InnateDB Gene
|
IDBG-58350 (GAL3ST3)
|
Protein Structure
|
|
Function |
Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha- 1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha- 1,4)GlcNAc. {ECO:0000269PubMed:11323440, ECO:0000269PubMed:11356829}.
|
Subcellular Localization |
Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in thyroid, brain, kidney, heart and spinal cord. {ECO:0000269PubMed:11323440, ECO:0000269PubMed:11356829}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
0
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0001733
|
galactosylceramide sulfotransferase activity
|
GO:0030246
|
carbohydrate binding
|
GO:0050656
|
3'-phosphoadenosine 5'-phosphosulfate binding
|
GO:0050694
|
galactose 3-O-sulfotransferase activity
|
GO:0050698
|
proteoglycan sulfotransferase activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR009729
Galactose-3-O-sulfotransferase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
|
PFAM |
PF06990
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q96A11
|
PhosphoSite |
PhosphoSite-Q96A11
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
89792
|
UniGene |
Hs.208343
|
RefSeq |
|
HUGO |
HGNC:24144
|
OMIM |
608234
|
CCDS |
CCDS8128
|
HPRD |
10501
|
IMGT |
|
EMBL |
AB053232
AY026481
BC113552
BC113554
|
GenPept |
AAI13553
AAI13555
AAK01945
BAB61900
|
|
|