InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRSS3

Summary

InnateDB Gene

IDBG-58425.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRSS3

Gene Name

protease, serine, 3

Synonyms

MTG; PRSS4; T9; TRY3; TRY4

Species

Homo sapiens

Ensembl Gene

ENSG00000010438

Encoded Proteins

IDBP-58427

protease, serine, 3

IDBP-58429

protease, serine, 3

IDBP-58433

protease, serine, 3

IDBP-366898

protease, serine, 3

IDBP-366899

protease, serine, 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010] This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:33750466-33799231

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000361005	ENSP00000354280
ENST00000342836	ENSP00000340889
ENST00000379405	ENSP00000368715
ENST00000457896	ENSP00000401249
ENST00000429677	ENSP00000401828
ENST00000468152
ENST00000477653
ENST00000495682

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0007586	digestion
GO:0009235	cobalamin metabolic process
GO:0031638	zymogen activation
GO:0043542	endothelial cell migration
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response