Version 5.4
Homo sapiens Protein: PRSS3
Summary
InnateDB Protein IDBP-366899.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRSS3
Protein Name protease, serine, 3
Synonyms MTG; PRSS4; T9; TRY3; TRY4;
Species Homo sapiens
Ensembl Protein ENSP00000401828
InnateDB Gene IDBG-58425 (PRSS3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0007586 digestion
GO:0009235 cobalamin metabolic process
GO:0031638 zymogen activation
GO:0043542 endothelial cell migration
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35030
PhosphoSite PhosphoSite-P35030
TrEMBL
UniProt Splice Variant
Entrez Gene 5646
UniGene
RefSeq NP_001184027
HUGO HGNC:9486
OMIM 613578
CCDS CCDS56570
HPRD 06685
IMGT
EMBL AB298285 AB298286 AF029308 AL139113 AL356489 AL358573 BC069476 BC069494 CH471071 D45417 X15505 X71345 X72781
GenPept AAC13322 AAH69476 AAH69494 BAA08257 BAF80324 BAF80325 CAA33527 CAA50484 CAB58178 EAW58482 EAW58484

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca