Version 5.4
Homo sapiens Gene: LHX5
Summary
InnateDB Gene IDBG-58868.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX5
Gene Name LIM homeobox 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089116
Encoded Proteins
IDBP-58870
LIM homeobox 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:113462034-113472280
Strand Reverse strand
Band q24.13
Transcripts
ENST00000261731 ENSP00000261731
ENST00000557836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007267 cell-cell signaling
GO:0021527 spinal cord association neuron differentiation
GO:0021549 cerebellum development
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021766 hippocampus development
GO:0021846 cell proliferation in forebrain
GO:0021879 forebrain neuron differentiation
GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0042127 regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029595
View Gene Order
ENSBTAG00000003107
Not yet available
Cross-References
SwissProt Q9H2C1
TrEMBL
UniProt Splice Variant
Entrez Gene 64211
UniGene Hs.302029 Hs.551307 Hs.709068
RefSeq NM_022363
HUGO HGNC:14216
OMIM 605992
CCDS CCDS9171
HPRD
IMGT
EMBL AF291181 BC109230
GenPept AAG36963 AAI09231
RNA Seq Atlas 64211

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca