Version 5.4
Mus musculus Gene: Lhx5
Summary
InnateDB Gene IDBG-195563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lhx5
Gene Name LIM homeobox protein 5
Synonyms Lim2
Species Mus musculus
Ensembl Gene ENSMUSG00000029595
Encoded Proteins
IDBP-195565
LIM homeobox protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089116:
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:120431770-120441223
Strand Forward strand
Band F
Transcripts
ENSMUST00000031591 ENSMUSP00000031591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007267 cell-cell signaling
GO:0021527 spinal cord association neuron differentiation
GO:0021549 cerebellum development
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021766 hippocampus development
GO:0021846 cell proliferation in forebrain
GO:0021879 forebrain neuron differentiation
GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0042127 regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000089116
View Gene Order
ENSBTAG00000003107
Not yet available
Cross-References
SwissProt P61375
TrEMBL Q543P4
UniProt Splice Variant
Entrez Gene 16873
UniGene Mm.5151
RefSeq NM_008499
OMIM
CCDS CCDS19617
HPRD
IMGT
MGI ID MGI:107792
MGI Symbol Lhx5
EMBL AK033927 AK048778 AK140208 BC057585 CH466529 U61155
GenPept AAC52842 AAH57585 BAC28517 BAC33455 BAE24281 EDL19774
RNA Seq Atlas 16873

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca