Version 5.4
Homo sapiens Gene: NMNAT3
Summary
InnateDB Gene IDBG-58929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NMNAT3
Gene Name nicotinamide nucleotide adenylyltransferase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163864
Encoded Proteins
IDBP-58931
nicotinamide nucleotide adenylyltransferase 3
IDBP-58933
nicotinamide nucleotide adenylyltransferase 3
IDBP-294360
nicotinamide nucleotide adenylyltransferase 3
IDBP-384530
nicotinamide nucleotide adenylyltransferase 3
IDBP-479520
nicotinamide nucleotide adenylyltransferase 3
IDBP-477385
nicotinamide nucleotide adenylyltransferase 3
IDBP-476089
nicotinamide nucleotide adenylyltransferase 3
IDBP-475120
nicotinamide nucleotide adenylyltransferase 3
IDBP-479336
nicotinamide nucleotide adenylyltransferase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:139560180-139678017
Strand Reverse strand
Band q23
Transcripts
ENST00000296202 ENSP00000296202
ENST00000339837 ENSP00000340523
ENST00000406164 ENSP00000384319
ENST00000413939 ENSP00000412953
ENST00000506254 ENSP00000423335
ENST00000511444 ENSP00000425041
ENST00000507242
ENST00000509447
ENST00000512391 ENSP00000426357
ENST00000509291 ENSP00000427634
ENST00000514703 ENSP00000426375
ENST00000509034
ENST00000509737
ENST00000511003
ENST00000505779
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000309 nicotinamide-nucleotide adenylyltransferase activity
GO:0003824 catalytic activity
GO:0004515 nicotinate-nucleotide adenylyltransferase activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0009058 biosynthetic process
GO:0009435 NAD biosynthetic process
GO:0009611 response to wounding
GO:0019674 NAD metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032456
View Gene Order
ENSBTAG00000047216
Not yet available
Pathways
NETPATH
REACTOME
REACT_11088
Nicotinate metabolism pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
hsa00760
Nicotinate and nicotinamide metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.733090
RefSeq NM_001200047 NM_178177 XM_006713628
HUGO
OMIM
CCDS CCDS3111 CCDS56282
HPRD 16370
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca