InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NMNAT3

Summary

InnateDB Protein

IDBP-58931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMNAT3

Protein Name

nicotinamide nucleotide adenylyltransferase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296202

InnateDB Gene

IDBG-58929 (NMNAT3)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury. {ECO:0000269PubMed:16118205, ECO:0000269PubMed:17402747}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:12574164, ECO:0000269PubMed:16118205}.

Disease Associations

Tissue Specificity

Expressed in lung and spleen with lower levels in placenta and kidney. {ECO:0000269PubMed:12574164, ECO:0000269PubMed:16118205}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity
GO:0003824	catalytic activity
GO:0004515	nicotinate-nucleotide adenylyltransferase activity
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009058	biosynthetic process
GO:0009435	NAD biosynthetic process
GO:0019674	NAD metabolic process
GO:0044281	small molecule metabolic process