Version 5.4
Homo sapiens Gene: STAM
Summary
InnateDB Gene IDBG-59071.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAM
Gene Name signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Synonyms STAM-1; STAM1
Species Homo sapiens
Ensembl Gene ENSG00000136738
Encoded Proteins
IDBP-59073
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
IDBP-59075
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
IDBP-368131
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:17644125-17715914
Strand Forward strand
Band p12.33
Transcripts
ENST00000377524 ENSP00000366746
ENST00000377500 ENSP00000366721
ENST00000445846 ENSP00000400025
ENST00000486183
ENST00000494250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 80 [view]
Protein-Protein 76 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0016197 endosomal transport
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0061024 membrane organization
Cellular Component
GO:0005829 cytosol
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026718
View Gene Order
ENSBTAG00000002658
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_14
IL2 pathway
NetPath_16
IL4 pathway
NetPath_19
IL-7 pathway
REACTOME
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04630
Jak-STAT signaling pathway pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.335391
RefSeq NM_003473 XM_005252603
HUGO
OMIM
CCDS CCDS7122
HPRD 03542
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca