InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAM

Summary

InnateDB Protein

IDBP-59073.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAM

Protein Name

signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Synonyms

STAM-1; STAM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000366746

InnateDB Gene

IDBG-59071 (STAM)

Protein Structure

UniProt Annotation

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Subcellular Localization

Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:8780729}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	80 [view]
Protein-Protein	76 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0016197	endosomal transport
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0061024	membrane organization